[Epilepsy with onset between the ages of 3 and 12 months. Our experience gained over a 10-year period]. / Epilepsia de inicio entre los 3 y 12 meses de edad. Nuestra experiencia de 10 años.

INTRODUCTION: The prognosis of epilepsy is essentially determined by its aetiology and a poorer prognosis is generally associated with an early onset of the seizures. PATIENTS AND METHODS: In this study we review our experience in epilepsies in children born after 1st January 1997 and who had their first acute non-symptomatic seizure before 31st March 2007 and between the ages of 3 and 12 months. Special attention is given to the analysis of cases of remote non-symptomatic epilepsies. RESULTS: Of the children born in that period, 267 were diagnosed with epilepsy, and the first seizure occurred between 3 and 12 months of age in 69 cases: 39 of which were symptomatic and 30 were cryptogenic and idiopathic epilepsies. West's syndrome/childhood spasms were observed in 20 cases (17 of the symptomatic cases and three of the cryptogenic and idiopathic patients). The cryptogenic and idiopathic cases were divided into three groups depending on their electroencephalogram pattern: nine generalised, 18 with no generalised alterations and three hypsarrhythmias. In addition, the three groups were analysed taking into account three degrees of psychomotor development: normal, slight retardation and moderate/severe retardation. None of the non-generalised cases presented severe psychomotor retardation, whereas 78% of the generalised and 33% of those with West's syndrome developed an important degree of retardation in their course. CONCLUSIONS: Our experience is compatible with the existence of epilepsies that have their onset in the early months of life and a good prognosis, which is important when it comes to the information and therapeutic approaches in cases of remote non-symptomatic epilepsy.

Epilepsia de inicio entre los 3 y 12 meses de edad. Nuestra experiencia de 10 años / Epilepsy with onset between the ages of 3 and 12 months. Our experience gained over a 10-year period

Introducción. El pronóstico de la epilepsia viene determinado fundamentalmente por su etiología y, en general, se asocia un peor pronóstico al comienzo precoz de las crisis. Pacientes y métodos. En este trabajo se revisa nuestra experiencia en epilepsias en niños nacidos tras el 1 de enero de 1997 y que presentaron la primera crisis no sintomática aguda antes del31 de marzo de 2007 y entre los 3 y los 12 meses de edad. Se analizan especialmente los casos de epilepsias no sintomáticas remotas. Resultados. De los niños nacidos en ese período, 267 tienen el diagnóstico de epilepsia y la primera crisis entre 3 y 12 meses se dio en 69 casos: 39 epilepsias sintomáticas y 30 criptogénicas e idiopáticas. Veinte manifestaron un síndrome deb West/espasmos infantiles (17 de las sintomáticas y tres de las criptogénicas e idiopáticas). Se clasifican las criptogénicas e idiopáticas en tres grupos según su patrón electroencefalográfico: 9 generalizadas, 18 sin alteraciones generalizadas y 3 hipsarritmias. Asimismo, se han analizado los tres grupos considerando tres opciones de desarrollo psicomotor: normal, retraso leve y retraso moderado/grave. Ningún caso de las no generalizadas presentó retraso psicomotor grave, mientras que el 78%de las generalizadas y el 33% de los síndromes de West desarrollaron un retraso importante en su evolución. Conclusiones. Nuestra experiencia es compatible con la existencia de epilepsias de presentación en los primeros meses de vida y buen pronóstico, lo cual es importante en la información y planteamientos terapéuticos de los casos de epilepsia no sintomática remota

Introduction. The prognosis of epilepsy is essentially determined by its aetiology and a poorer prognosis isgenerally associated with an early onset of the seizures. Patients and methods. In this study we review our experience in epilepsies in children born after 1st January 1997 and who had their first acute non-symptomatic seizure before 31st March 2007 and between the ages of 3 and 12 months. Special attention is given to the analysis of cases of remote non-symptomaticepilepsies. Results. Of the children born in that period, 267 were diagnosed with epilepsy, and the first seizure occurred between 3 and 12 months of age in 69 cases: 39 of which were symptomatic and 30 were cryptogenic and idiopathic epilepsies. West’s syndrome/childhood spasms were observed in 20 cases (17 of the symptomatic cases and three of the cryptogenic andidiopathic patients). The cryptogenic and idiopathic cases were divided into three groups depending on their electroencephalogram pattern: nine generalised, 18 with no generalised alterations and three hypsarrhythmias. In addition, the three groups were analysed taking into account three degrees of psychomotor development: normal, slight retardation and moderate/severe retardation. None of the non-generalised cases presented severe psychomotor retardation, whereas 78% ofthe generalised and 33% of those with West’s syndrome developed an important degree of retardation in their course. Conclusions. Our experience is compatible with the existence of epilepsies that have their onset in the early months of life and a good prognosis, which is important when it comes to the information and therapeutic approaches in cases of remote nonsymptomaticepilepsy